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A more precise assessment is required of both the anxiolytic and anxiogenic potentials of phytocannabinoids, with an aim towards the development of the holy grail in cannabis research, a medicinally-active formulation which may assist in the treatment of anxiety or mood disorders without eliciting any anxiogenic effects

JAMA 274 , 225233 (1995)

Later in the game, Gilbert Renton also asks for a gun to take out the gangster Jojo Fine by himself, and again, the decision to give him one or not has some (minor) effect on the plot